What is Retatrutide?

Retatrutide (often referred to as RETA) is an investigational peptide medication being developed as a once-weekly injection targeting three key hormones to help regulate appetite and metabolism.

How does it work?

Retatrutide targets the following hormone receptors:

• GLP-1 Enhances insulin secretion and promotes satiety.

• GIP Stimulates insulin release after meals.

• Glucagon: Regulates glucose production in the liver and increases energy expenditure.

By activating these receptors, retatrutide helps reduce appetite, improve blood sugar control, and promote weight loss.

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What do I get?

Retatrutide is typically supplied as a freeze-dried (lyophilised) powder in a small 20mg vial. Before use, it must be reconstituted (Mixed) with two millilitre of bacteriostatic water. This involves slowly adding the water for injection to the vial and gently mixing until the powder is fully dissolved. Injections of 1mL (10 units on 1mL syringe) will give you 20 injections of 1mg of Retatrutide. 

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How often do I use it?

Injections are usually administered once a week, starting with 0.5mg at week one and moving up to 3mg on week three. 

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How do I prepare for use?

To reconstitute the Retatrutide you will need additional items:

Shringes - 1ml Insulin - EG: https://amzn.eu/d/06IXjKNG

Bacterioustatic water - EG:  https://amzn.eu/d/0aBduzbc

Alcohol wipes - EG: https://amzn.eu/d/073r0cc1

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Steps to Reconstitute Peptides.

Reconstituting peptides is a straightforward process that ensures accurate dosing and preserves the peptide's integrity. Follow these steps carefully:

• Clean the Vial Tops:

  • Swab the rubber stoppers on both the peptide vial and the bacteriostatic water vial with alcohol wipes. Allow them to air dry.

• Draw the Solvent:

  • Using the insulin syringe, draw the desired amount of bacteriostatic water.

• Inject the Water:

  • Insert the needle into the peptide vial at a slight angle. Slowly inject the bacteriostatic water down the inside wall of the vial to minimise bubbling.

• Dissolve the Peptide:

  • Gently swirl the vial until the powder is fully dissolved. Avoid shaking the vial, as this can damage the peptide structure.

You can learn how to properly reconstitute peptides here: https://youtu.be/n8vk8DfwRHg

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How do I inject?

Preparing for Injection

• Wash Hands: Clean your hands thoroughly with soap and water or an alcohol-based hand sanitiser.

• Select Injection Site: Common sites include:

  • Abdomen (avoid the area around the navel)

  • Upper outer thighs

  • Upper outer arms (if someone else is administering)

Administering the Injection

• Clean the Injection Site: Use an alcohol pad to clean the area where you will inject.

• Draw the Dose: Draw the prescribed dose into the syringe.

• Pinch the Skin: Pinch a fold of skin at the injection site.

• Insert the Needle: Insert the needle at a 45-degree angle into the fatty tissue just beneath the skin.

• Inject the Peptide: Push the plunger to deliver the medication.

Post-Injection Care

• Dispose of the Needle: Place the used syringe in a sharps container immediately.

• Monitor the Injection Site: Look for any signs of irritation or adverse reactions.

 

IMPORTANT TIPS

• Rotate Injection Sites: To prevent tissue damage, always use a new site at least 1-2 inches away from the previous injection.

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How do I store my Retatrutide?

• Reconstituted peptides have a shelve life of approximately 28days and should be stored at a temperature of 2-8 degrees Celsius.

• Store reconstituted vials in the back of the fridge, not the door (which has temperature swings).

• Minimise time out of the fridge: Draw your dose quickly (under 2 minutes) and return the vial immediately.

• Protect from light: UV and visible light degrade peptides .

 

Are there any side effects?

Users report varying levels of feeling nausea when first using Retatrutide. 

The most common side effects of Retatrutide are listed below. These side effects may vary depending on the dose. These symptoms may or may not exist. This will depend on the individual. They may exist in isolation and not all together. Many users report some symptoms lessen over time and use of the product. 

• Headache

• Nausea or vomiting

• Diarrhoea

• Constipation

• Abdominal Discomfort

 

Resourses

Peptide Mixing, Dosing and Injecting Safely Video:

https://youtu.be/3VmMvS43Hz0?si=OxonXvV1OzKZzg0a

 

Equipment:

Shringes - 1ml Insulin - EG: https://amzn.eu/d/06IXjKNG

Bacterioustatic water - EG:  https://amzn.eu/d/0aBduzbc

Alcohol wipes - EG: https://amzn.eu/d/073r0cc1

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